Sentence examples for multiple proteases in from inspiring English sources

Alternatively, the peptide identified may be the product of a cleavage event mediated by another protease, as PepD was able to co-immunoprecipitate multiple proteases in both M. tuberculosis and M. smegmatis.

Despite the presence of multiple proteases in the food vacuole, it is noteworthy that treatment of cultured parasites with specific inhibitors of cysteine proteases fully blocked the hydrolysis of hemoglobin, highlighting the key role for the falcipains in this process [22].

Furthermore, since the role of multiple proteases in biological processes is well documented, the comparative study of degradomes may improve our understanding of these processes in different organisms.

The expression of multiple proteases in P. marinus may indicate their role(s) in processing the host protein substrates to facilitate uptake of their metabolic products to sustain normal cell function and proliferation.

The hallmark of osteoarthritis (OA), cartilage degradation, is caused by an imbalance of anabolic and catabolic pathways with a shift toward increased catabolic pathways that include upregulation of multiple proteases in the OA joint.

Implications and future directions These results demonstrate that the activity of multiple proteases is increased in chondrocyte-enriched populations in ML-II zebrafish embryos, and that excessive activity of one of these proteases, cathepsin K, plays a central role in the cartilage morphogenesis defects and type II collagen accumulation observed in these animals.

Considering the fragmentation pattern of OPA1 in prohibitin knockdown cells, it seems most likely that multiple proteases are involved in OPA1 processing and not all of them are affected by prohibitin loss.

For instance, pY sites in SLP-76 remained undetectable even after using various single or combination of multiple proteases [unstated details in ref (19)].

Surprisingly, inhibition of cathepsin K activity not only resulted in phenotypic correction of the cartilage defects but also led to a general suppression of multiple protease activities in ML-II embryos.

Considering the complex role of PAR-1 in infection, related to the capacity of multiple proteases to activate PAR-1 resulting in differential cellular effects and the multiple cell types expressing PAR-1, this receptor at this moment does not represent a straightforward therapeutic target in severe pneumonia and sepsis.

In light of this, the multiple proteases linked with apoptotic cell death may be involved in releasing CD25 from the cell surface.