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Multiple, prospective trials have been performed comparing open and endovascular TAA repair with three company sponsored trials documenting clinical equipoise.
Multiple prospective trials have arrived at conclusions similar to those drawn by Freeman and coworkers (grade B) are present.
Recently, some multiple prospective trials of treatments for hypertension initiated a debate about the clinical impact of NOD in hypertensive patients [ 4– 8].
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Multiple prospective clinical trials and meta-analyses have demonstrated that the combination of a LABA and an ICS confers proven clinical benefits which appear greater than the rare risk for serious or life-threatening adverse events, although all of these studies have inadequate power to be definitive.
Multiple prospective randomized trials have shown no difference in survival between patients treated with BCT and those undergoing mastectomy, even after long-term follow up.
Although multiple prospective randomized trials and observational studies have demonstrated that mortality from colon cancer can be reduced with screening and removal of adenomatous polyps, compliance with screening guidelines remains low.
Time to being admitted to institutional care, for example, has been used as a criterion for evaluation of the clinical efficacy of putative therapeutics for Alzheimer's disease in multiple prospective clinical trials.
Regarding specific palliative radiation recommendations, the report cites multiple prospective randomized trials that demonstrate that a single large fraction of radiation, typically 8 Gy in one fraction, is as effective for pain control and more efficient than prolonged radiation schedules.
Future studies should emphasize large, prospective trials, assess multiple medications in individual subjects, and consider a full range of pharmacodynamic and pharmacokinetic outcomes.
Prospective trials in SLE, multiple sclerosis, and Crohn's disease are in progress or are being planned.
In the last 10 years, the standard of care for a patient with mRCC has undergone multiple revisions, mainly due to the rapidity of emerging data from prospective trials.
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