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Multiple prospective studies have demonstrated that insulin resistance predicts future CVD.
Multiple prospective studies have documented an association between insulin resistance and accelerated CVD in patients with type 2 diabetes, as well as in non-diabetic individuals.
(2) An accumulation of case control studies and (3) multiple prospective studies show that increased recreational and occupational physical activity levels are associated with reduced endometrial cancer risk.
Higher compared with lower blood estrogen and testosterone concentrations have been associated with breast cancer risk in multiple prospective studies [ 48- 53].
Elevations of inflammatory biomarkers (TNF-α and CRP) have been associated with increased risk of CVD in multiple prospective studies (13).
We also note that for both lead and hemoglobin, multiple prospective studies have demonstrated that exposures (high lead and low iron status) precede the decrease in neurological functions tested, and these associations are widely accepted.
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Individual participant time-to-event data from multiple prospective epidemiologic studies enable detailed investigation into the predictive ability of risk models.
Multiple large prospective studies have shown a protective effect of alcohol consumption against ischaemic heart disease, [ 31] and although heavy drinking is a risk factor for type 2 diabetes, and a number have shown that regular moderate consumption may also be a protective factor with increased insulin sensitivity [ 32, 33].
Mothers who are concerned about their young child's weight are more likely to use restrictive feeding, which has been associated with increased food seeking behaviors, emotional eating, and overeating in young children across multiple prospective and experimental studies.
Multiple retrospective and prospective studies have been published recently, defining these risks.
Although one prospective study showed evidence for association between long TL and increased breast cancer risk (12), two different meta-analyses of TL and breast cancer risk based on multiple retrospective and prospective studies concluded there was no overall evidence of association (6, 8).
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