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Each of the 104 MDR- MTB isolates was tested for FQ susceptibility using the Multiple Proportion Method in agar.
A multiple proportion comparison of CRLI and CRBSI incidence density between the different catheter accesses was performed using the Fisher–Freeman–Halton exact test.
These isolates had previously been tested for susceptibility to rifampin and isoniazid using a screening test in thin layer agar Middlebrook 7H11 (TLA 7H11) (Becton Dickinson) [ 24] and confirmed as MDR-TB using the Multiple Proportion Method in agar [ 25].
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As the Swedish chemist Jöns Jacob Berzelius wrote to Dalton: "The law of multiple proportions is a mystery without the atomic theory".
Ostwald even attempted to derive the basic chemical laws of constant and multiple proportions without the help of the atomic hypothesis.
Thus, Gay-Lussac's law relates volumes of the chemical constituents within a compound, unlike Dalton's law of multiple proportions, which relates only one constituent of a compound with the same constituent in other compounds.
On the basis of the law of definite proportions, Dalton deduced the law of multiple proportions, which stated that when two elements form more than one compound by combining in more than one proportion by weight, the weight of one element in one of the compounds is in simple, integer ratios to its weights in the other compounds.
Dalton predicted that, when two elements combine in a series of compounds, the ratios of the masses of one element that combine with a fixed mass of the second are reducible to small whole numbers; this is now known as the law of multiple proportions.
Dalton's measurements, crude as they were, allowed him to formulate the Law of Multiple Proportions: When two elements form more than one compound, the masses of one element that combine with a fixed mass of the other are in a ratio of small whole numbers.
This is the law of multiple proportions, predicted by Dalton and soon confirmed by a range of experiments.
The contemporary laws of constant and multiple proportions deal with a concept of elemental proportions understood on the basis of the concept of mass.
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