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fru is a complex locus with multiple promoters encoding putative transcription factors [ 12, 13].
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The genes encoding IDO1 and IDO2 utilize multiple promoters to express transcripts of different lengths and generate both active and truncated proteins [4], [5]; their expression in stem cells remains to be characterized.
In addition, most PDE genes encode for multiple splicing variants through the use of multiple promoters and alternative splicing.
Transcription is performed by a phage-type RNA polymerase encoded by the nucleus [ 3] and the presence of multiple promoters is a common feature of plant mt genes [ 4, 5].
Multiple promoters upstream of many bacterial genes pose another challenge to their classification.
Five exons encode an hRFC protein consisting of 591 amino acids with 12 transmembrane domains [ 9]. hRFC is subject to intricate regulation of gene expression involving multiple promoters and non-coding exons [ 9].
The multiple promoters from the same gene were summarized.
Similar multiple promoters have been identified in plant mitochondria [ 75].
When multiple promoters have been employed, interference has occurred between promoters leading to promoter suppression and rearrangement.
Most human genes have multiple promoters and each promoter has multiple TSSs (Frith et al., 2008; Sandelin et al., 2007).
The occurrence of multiple TSSs can be explained by the presence of multiple promoters.
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