Sentence examples for multiple proinflammatory cytokines from inspiring English sources

TNFα can be used as a surrogate marker for an inflammatory response because it is known to play an important role in the orchestration of multiple proinflammatory cytokines (Feldmann and Maini 2003; Parameswaran and Patial 2010).

In total, PS2 deficiency impacts multiple proinflammatory cytokines as measured in our assay.

ASM cells can contribute directly to the pathogenesis of asthma by expressing cell adhesion and co-stimulatory molecules and by secreting multiple proinflammatory cytokines and chemokines that may perpetuate airway inflammation and the development of airway remodeling in vivo [4].

Moreover, analysis of the cytokine expression in this CD4+CD25+CCR4+Foxp3− T cell subset demonstrated that these cells were unique because they produce multiple proinflammatory cytokines such as IL-2, IL-17, and few IFN-γ in healthy individuals while CD4+CD25+CCR4+Foxp3+ T cells (Treg cells) did not (Figure 4).

In addition to their proliferative and contractile properties, studies suggest that ASM cells can contribute directly to the pathogenesis of asthma by expressing cell adhesion and costimulatory molecules and by secreting multiple proinflammatory cytokines and chemokines that may perpetuate airway inflammation and the development of airway remodeling in vivo[2].

NF-κB modulates the induction of multiple proinflammatory cytokines, including interleukin (IL -1β, IL -1βnd tumor necrosis factor (TNF)-α, and is also induced by these proinflandatumorcytokinecrosis, so that excessive NfactorcTNF -α due TNF -αdequand nuclear isalsovatinducedld contribythese severity of immune-mediated disease symproinflammatory

Patients with severe burn injury experience a rapid elevation in multiple circulating proinflammatory cytokines, with the levels correlating with both injury severity and outcome.

β-cell apoptosis can be induced by multiple stimuli including proinflammatory cytokines and long chain NEFAs in both type 1 and type 2 diabetes [ 9, 34].

Intravitreal injection of the corticosteroid triamcinolone has been shown to result in decreased aqueous humor concentrations of multiple proinflammatory and angiogenic cytokines, including VEGF, that are associated with vascular leakage and macular edema [ 3].

In addition to IL1, there was also a strong activation of immune response as illustrated by the upregulation of multiple proinflammatory chemokines and cytokines as well as NFKB cascade (e.g. IL1A, IL1B, NFKB complex, IL-1, IL-15, IL-17A, IL-18, Toll-Like Receptor (TLR -4) and TLR -4upstreandand downstheir target molecupstreamg.  5b).

The loss of I κB α results in the release of the free NF- κB subunit p65, which translocates from the cytoplasm to the nucleus, where it triggers the transcription of multiple proinflammatory genes, including cytokines (TNF- α, IL-1 β, iNOS, COX2, etc)., chemokines, and adhesion molecules [ 31, 32].