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The observations reported here suggest the existence of multiple prognostic subtypes of HER2-positive breast cancer, characterized by the co-expression of HER2, HER3, and/or p95, and are consistent with current models of trastuzumab resistance.
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Multiple prognostic and predictive imaging biomarkers have been identified.
In both cases, gene expression signatures were proposed to predict these prognostic subtypes.
Identification of interactions between immune response and other molecular pathways may define novel prognostic subtypes.
Multiple prognostic factors can be adjusted for using multivariate modelling.
All these score systems are based on multiple prognostic parameters.
From the survival analyses with DFS and OS, HER2 subtype was the worst prognostic subtype among four-or five subtypes (Table 4) (HR, 3.07, 95% CI, 1.86-4.87; P < 0.001).
Without chemotherapy, BLBCs were worst prognostic subtype in both DFS and OS.
Multiple histologic subtypes were represented.
BBD comprises multiple histologic subtypes.
In contrast, subtype H7 viruses with multiple NA subtypes have successfully transmitted from birds to humans, suggesting that multiple NA subtypes are compatible with the subtype H7 HA.
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