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Additional and possibly multiple prognostic predictors may help improve the prediction models by helping better discriminating the patients with different possible disease outcomes [ 4].
Rather than relying on two or three prognostic stratification factors in randomised trials, this nomogram represents an important advance and will allow better patient stratification in trials using multiple prognostic predictors evaluated simultaneously.
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Both univariate and multiple analysis concerning death or metastasis (Table 5) revealed that tumour stage and nodes were prognostic predictors for oncological outcome.
Interestingly, PDE4PIP, the top predictor gene in this prognostic analysis, appeared to be targeted by multiple prognostic miRNAs, potentially strengthening the specificity of a biological hypothesis.
Multiple prognostic and predictive imaging biomarkers have been identified.
The results of studies identifying these prognostic predictors are often inconclusive or contradictory.
NSS also appear as useful prognostic predictors for functional outcome, response and tolerance to antipsychotics.
Studied primary outcomes depended on the series and multiple prognostic factors have been identified.
Coincidences with other prognostic predictors were assesed.
Few published prognostic predictors have met these criteria [ 13, 14].
Table 3 shows the final model of prognostic predictors.
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