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[14] reported gene expression profiles in 38 distinct purified populations of human hematopoietic cells ranging from hematopoietic stem cells, through multiple progenitor and intermediate maturation states, to 12 terminally differentiated cell types.
Using these methods, together with Pearson's correlation analysis coupled to a visual display of the image data, we performed pairwise comparisons of multiple markers in the same tissue sections to quantify the spatio-temporal distribution of cells positive for multiple progenitor and differentiation markers over time.
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The egr-5 RNAi) egr-5 RNAiresulting in the exphenotypef neoblasts and multiple presulting populatinns reveals thet complexpansioncs are at play between differentiating profeneoblastsw neoblands respond to loss of tissue integrity.
Interestingly, our data indicate that the spectrum of cell types that are c-kit positive changes developmentally and suggests that multiple progenitor cell populations may contribute to SMG development and tissue homeostasis.
Disruption of epidermal integrity by egr-5 RNAi triggers a global stress response that induces the proliferation of neoblasts and the concomitant expansion of not only epidermal, but also multiple progenitor cell populations.
We describe multiple progenitor subgroups, showing unexpected transcriptional priming toward seven differentiation fates but no progenitors with a mixed state.
These results, together, suggest that the primary prostatic basal cells have the capacity to differentiate into neural progenitor-like cells, evidenced by expression of multiple progenitor but not mature neuronal markers.
Egr-5 knockdown results in the expansion of multiple progenitor populations.
It has been suggested that they may arise from radial glial progenitor cells in the Ventricular Zone (VZ) [ 11], but it is still unclear whether they derived from a single or multiple progenitor cell, or whether they arise at a particular moment or at different times during the proliferation phase [ 12].
The survival outcomes were calculated as time elapsed from date of operation until date of death Since multiple progenitor cells express NG2 during normal tissue development, we aimed to establish whether NG2 was co-expressed with other markers of immature cells in GBM tumours.
The resulting loss of epidermal integrity is sensed by the neoblasts (induced stress response) and causes an expansion of neoblasts and multiple progenitors before animals eventually lyse due to irreparable loss of an intact epidermal barrier.
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