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Three patients were untreated at the time the biopsy was taken, including the patient with anaplastic MM, whereas two patients had received multiple prior lines of therapy.
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Atwell et al. [12] genotyped 107 lines of Arabidopsis with the 250K array to determine which SNPs were polymorphic between two given lines to a high degree of confidence, using quality ensuring measures such as multiple prior data sets for sequence confirmation, the filtering of bad arrays and bad SNPs using mismatch rates, and removing non-binary SNPs.
Multiple prior studies have shown that testosterone therapy may protect against heart disease and decrease mortality.
All patients had received multiple prior therapies.
[ 3] These results are supported by multiple prior studies.
13 34 35 Using multiple prior prescriptions will maximise power.
Maximal two prior lines of myelosuppressive chemotherapy were allowed.
Up to three prior lines of chemotherapy were permitted.
In the platinum-sensitive patient cohort, 74% had 1 prior line and 26% had 2 prior lines.
One should note that nine of the 12 responders to ixabepilone had not responded to prior multiple lines of chemotherapy in the metastatic setting, including combination regimens.
Phase I and II studies reveal good tolerance and preliminary single agent clinical activity for lapatinib monotherapy despite multiple lines of prior chemotherapy and trastuzumab, indicating lapatinib activity beyond failure of standard therapies.
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