Sentence examples for multiple prion strains from inspiring English sources

Furthermore, a wealth of experimental data supports the "protein-only" model, which implies that PrPSc itself is the infectious prion agent1,2,3,4,5,6,7,8,9,10. One of the most intriguing and still poorly understood aspects of prion diseases is the existence of multiple prion strains that give rise to different disease phenotypes within the same mammalian species1,2,3.

In 2012, Supattapone and colleagues purified the membrane lipid phosphatidylethanolamine as a solitary endogenous cofactor capable of facilitating the formation of high-titer recombinant prions derived from multiple prion strains.

Multiple prion strains have been isolated from some cases of natural sheep scrapie [30], [31].

Thus, it remains to be further clarified whether CWD may be caused by multiple prion strains with distinct transmission properties.

The reason why multiple prion strains emerged during intra- and interspecies transmission in this study is unclear.

Different phenotypes may be explained by the existence of multiple prion strains which in experimental animals may be distinguished by their characteristic incubation times, neuropathology and biochemistry.

Interspecies prion transmission can alter CWD host range (38 ) and yield multiple novel prion strains (3, 28 ).

46– 48 However, some of these studies required multiple passages of the specific prion strains to confirm the strain or disease.

On the one hand, this demonstrates the interest of such a simple biochemical test to refine PrP analysis, and on the other hand it raises a question about the existence of different PrPres signatures in the same patient, i.e., different prion strains linked to multiple infections or to variants selected by the host.

Subclone L929 15.9 persistently propagates prions when infected with prion strains 22L or RML (Suppl. Table).

Although several putative prion receptors have been described, their role for the establishment of prion infection and their engagement with different prion strains is unclear22, 23, 73.