He affirms this point a few lines later, repeating the ancient view of number as multiples of the primordial "unity".
Cells may have rapidly evolved systems of regulation that exploit these differences and that allow coordination of the multiple functions of the primordial molecules.
In addition, since mouse Gtl2 (Meg3) is expressed in multiple fetal tissues including the primordial cartilage, this may argue for the positive role of absent MEGs expression in phenotypic development.
Women with FSHR-inactivating mutations develop multiple follicles in the early primordial, primary, secondary and pre-antral stages, but no antral or pre-ovulatory follicles (as their development is FSH-dependent) and such mutations are rare causes of POI (Aittomaki et al., 1995; Doherty et al., 2002).
We observed that the NANOS3 protein was expressed during multiple stages of human oogenesis, including primordial, primary, secondary and antral follicles (Fig. 2A C) with the highest expression in the oocytes; negative controls did not demonstrate specific staining (Fig. 2D F).
Are viruses as a whole monophyletic, i.e., ultimately descend from a single primordial virus or polyphyletic, i.e., have multiple origins?
Differentiation of primordial germ cells into mature spermatozoa proceeds through multiple stages, one of the most important of which is meiosis.
On the other hand, the LanL family may have evolved via gene fusion events among stand-alone Ser/Thr kinases, pSer/pThr lyases, and LanC-like cyclases, which retained their primordial substrate promiscuity that allows these enzymes to process multiple Ser/Thr residues in a substrate peptide.
Complement is a primordial sentinel of the innate immune response that engages in multiple inflammatory cascades as it becomes activated during tissue injury and remodeling.
