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Multiple primary neoplasms in surviving cancer patients are relatively common, with an increasing incidence.
7, 9, 22 Family history is an important risk factor for multiple primary neoplasms.
Other recurrent clinical characteristics are presence of multiple primary neoplasms in the same individual and cancer familiarity.
This was a retrospective review of clinical data for all consecutive patients with histologically confirmed cancer, with emphasis on single versus multiple primary neoplasms.
9, 10 The overall incidence of multiple primary neoplasms among cancer survivors varies widely in the literature from 1%to37%7%, depending on the type of analysis used, timing of data collection, and ethnicity of the subjects studied.
Biopsy should be performed only in cases of unknown primary tumour or multiple primary neoplasms or when there is doubt if the lesion is a secondary localization of the known primary neoplasm.
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From this registry, 132 consecutive multiple primary neoplasm (MPN) patients where one or both the primaries were tobacco related, and their genomic DNA and consent were available, were taken up for this study.
To study the association of SULT1A1*2 polymorphism with tobacco-related cancers (TRCs), a case control study comprising 132 patients with multiple primary neoplasm (MPN) involving TRC and 198 cancer-free controls was carried out.
Recent reviews emphasized age as a risk factor for the development of multiple primary malignant neoplasms [ 25, 26].
Primary neoplasms consist of multiple subpopulations of cells with heterogeneity in diverse properties, such as gene expression, karyotype, growth rate, antigenicity/immunogenicity, cell surface receptors, marker enzymes, sensitivity to different cytotoxic drugs, invasion, and metastasis [ 3, 4, 34].
Thus, in each patient these neoplasms could represent (i) multiple primary lung cancers, or (ii) primary lung cancer and derived metastatic lesions.
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