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Coding of multiple primaries followed the principles of International Association of Cancer Registries IACR and International Agencycy for Research on Cancer (IARC) [ 21- 23].
Coding of multiple primaries followed a common set of rules proposed by the International Agency of Cancer Registries (IACR) and the International Agency for Research on Cancer (IARC) [ 21].
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The reported incidence of multiple primaries may be underestimated because the duration of follow-up for some patients was relatively short, and a longer follow-up, logically, will reveal development of more second primaries.
However, this is unlikely as we have excluded all tumors that do not follow the SEER guidelines for multiple primaries.
Warren and Gates defined the criteria for multiple primary malignant neoplasia as follows: 1) each tumor must definitively exhibit malignancy; 2) each tumor must be distinct; and 3) the probability of a tumor being a secondary metastatic lesion of the other tumor must be reasonably excluded [ 13].
Coding of multiple primary cancers followed a common set of rules proposed by the International Association of Cancer Registries and the IARC [26].
An ad hoc study of the diagnostic accuracy of second cancers in the Swedish Cancer Registry indicated that 98% were correctly classified 10, and the German cancer registries strictly followed the multiple primary coding rules of the International Agency for Research on Cancer IARCCancer IARC
Those candidacies withered once they headed south for the multiple primaries in larger states.
Women whose first primary is the breast account for 25% of survivors with multiple cancers, followed by colorectal cancer (15%) as the first primary in both men and women, according to SEER data. 2 In the present study, the most common initial primary among cancer survivors with multiple primaries for both men and women was breast, prostate, and colorectal.
The possibility of multiple primary malignancies should always be considered during the treatment and follow-up of cancer patients, especially those of Caucasian ancestry and those having a strong family history of cancer.
We then conducted a priori data analysis with primary attention to the effects of multiple testing, followed by a posteriori data analysis for refinement of hypotheses and guidance of future work.
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CEO of Professional Science Editing for Scientists @ prosciediting.com