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aPatients could have received multiple previous therapies.
Most if not all had been tried on multiple previous therapies including those for GERD, CVA and UACS.
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Although good outcomes can still be seen in patients who have received multiple previous lines of therapies, and those who are considered refractory to therapy at the time of transplant, both of these factors do adversely affect expected outcomes.
Parameters such as the absence of Rheumatoid Factor or anti-CCP antibodies, multiple previous exposures to anti-TNF-α therapies, and high levels of circulating preplasma cell and subsequent incomplete depletion, have been recognized as predictors of treatment failure (Cohen et al., 2006; Thurlings et al., 2008; Vital et al., n.d).
If multiple genotypes with the same number of previous therapies were available for the same patient, only the earliest was considered.
The last twelve years have witnessed the development of new therapies for relapsing-remitting multiple sclerosis that demonstrate increased efficacy relative to previous therapies.
Development of multiple primaries in cancer survivors may be related to increased awareness or be secondary to previous therapies, and may also be due to shared risk factors, including environment, lifestyle, and inherited genes.
Hayden told me that he agreed, because he "had multiple previous such orders from D.O.J".
All the previous therapies were progressively (2 months) discontinued.
Multiple previous investigations have shown benefit from this surgical technique.
Turkey has remained a NATO member for 64 years, despite multiple previous military coups.
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CEO of Professional Science Editing for Scientists @ prosciediting.com