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A suitable methodologically robust study design would be to sample treatment naïve individuals with a first episode and multiple previous episodes of illness and compare treatment effectiveness between the groups.
Joyce et al. (2016) proposed that a methodologically robust study design to answer the question of whether treatment is more effective earlier in illness course would be to sample treatment-naïve individuals with a first episode and multiple previous episodes of illness and compare treatment effectiveness between the groups.
Submitted] in preventing recurrences over a 2-year follow-up and also over 5.5 years in patients with multiple previous episodes [ 19].
Recently, the preventive effects of CT in primary care have been confirmed in patients who have experienced multiple previous episodes [ 20].
Optimizing long-term outcomes is therefore an important goal in the treatment of MDD, especially for well-known high risk groups, i.e. patients with multiple previous episodes and/or residual symptoms.
In line with other studies on CT, we found that CT was effective (and cost-effective: Bockting CLH, Dijkgraaf MGW, Hakaart-van Roijen L et al.: Cost-effectiveness of relapse-prevention cognitive therapy in recurrent depression: a two year study, submitted) in preventing recurrences over a 2-year follow-up and even over 5.5 years [ 7], in patients with multiple previous episodes.
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Risk factors related to prolonged disease at diagnosis, including history of multiple previous treatment episodes, emphasize that the initial treatment episode is also likely the best chance of cure.
Risk factors for poor treatment outcomes at EOT and EOS include both patient factors (diabetes status, age, BMI) and disease factors (history of multiple previous treatment episodes, MDR-TB).
Aside from general risk factors such as comorbid medical problems, older age, multiple medications, and previous episodes of delirium, patients with HAD are the highest risk group to develop delirium.
David A. Goodman comments on the DVD commentary that "It's nice to hear Mike Barker back on Family Guy.," as Barker had performed multiple voices of characters in previous episodes.
The aim is to highlight a potential methodological limitation common to many studies comparing bipolar patients with few previous episodes versus those with multiple episodes, and in which the results are interpreted as indicating the longitudinal course of the illness.
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several previous episodes
multiple previous instances
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multiple previous reports
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multiple depressive episodes
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