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Considering the amount of data and the efficiency of analysis, a one-hour recording time was sufficient to obtain necessary data in the multiple preliminary studies using various recording times.
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Using the same strain for all NTP studies would minimize the need to conduct multiple preliminary and toxicokinetic studies and enhance comparability across study end points.
For control animals, multiple slices from three animals were counted at the 6 week time point, but from only one control animal at the 8 week time point, as preliminary studies on multiple (n = 3) control animals found no change in percent GluR2-positive cells at three time points over a 3 month period (unpublished observations).
Sheffler LR, Hennessey MT, Knutson JS, Chae J. Neuroprosthetic effect of peroneal nerve stimulation in multiple sclerosis: a preliminary study.
Second, we will sketch two preliminary studies on multiple-look effects from our laboratory.
Preliminary studies of this region indicate the possibility of multiple loci contributing to the QTL, acting in an additive fashion.
Preliminary studies to find targets of miR-200a have identified multiple genes that are targeted by this microRNA (Fig. 4A), and represent potential mediators of the miR-200a-induced effects observed in culture.
Although preliminary studies have been encouraging [ 29], more data from multiple centers is awaited.
We will now briefly describe two preliminary studies done in our laboratory to investigate whether multiple-look effects can be demonstrated in continuous sequences.
This study and other preliminary studies indicate that a ratio <1 may be relatively safe in a patient without multiple risk factors [ 11- 13].
Although multiple preliminary lines of evidence suggest enhanced clinical response rates with dose-intense regimens, there are no published studies to date documenting the effect of these temozolomide schedules on MGMT activity in brain tumour.
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