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High-risk pregnancies in the UK are thought to be linked to obesity, IVF, social deprivation and multiple pregnancies as well as increased maternal age and poorer access to health care, especially in some ethnic minority communities.
The third was a register of all pregnancies of twins, triplets or other multiple births.What made this last register so useful was that it recorded multiple pregnancies as soon as they were recognised ultrasonically, rather than at birth.
There is still a need for properly designed randomized controlled trials to compare day 3 with day 5 transfer which will also address the effectiveness of a single blastocyst replacement in reducing the incidence of multiple pregnancies as well as the value of blastocyst cryopreservation.
This allows for a more robust estimate of the overall treatment effect of progestogen on multiple pregnancies as well as a more conclusive evaluation of any harmful effects.
It is biologically plausible to apply the study findings to singletons and higher order of multiple pregnancies as well, although the magnitude of the differences may be smaller in singletons and larger in higher order of multiple pregnancies than in twins.
1 This study was thus designed to investigate time trends in preterm birth rates in the Euro-Peristat countries, and how these trends differ for singleton versus multiple pregnancies, as well as preterm deliveries with a spontaneous versus a non-spontaneous onset of labour.
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We excluded women with multiple pregnancy as well as those who had induced deliveries or any type of cesarean section (SC) including intrapartum SC.
Planned subgroup analysis will be performed to assess the consistency of a treatment effect among various patient characteristics i.e. cervical fibronectin status, presence of ruptured membranes, multiple pregnancy as well as cervical length at study entry.
While we have been intentionally cautious around interpretation of findings relating to carer/hospital recommendation and multiple pregnancy as reasons for caesarean, it is possible that the absence of these options may have altered how women responded to the question.
We will use a randomised trial (the ProTwin-trial: Pessaries in multiple pregnancy as a prevention of preterm birth: the ProTwin Trial) to assess the effect of a cervical pessary on neonatal outcome.
13 14 15 Live birth rates with the transfer of one good quality embryo are 28% per cycle, with multiple pregnancy rates as low as 1% per live birth.
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