This localized enrichment of PIP2 and PIP3 is due to multiple factors, including preferential trapping of the lipids within lipid rafts, binding proteins concentrating PIPs in specific membrane locales, and localized recruitment of enzymes which synthesize PIPs.
Extensions of the method to generate media with multiple pore structures and preferential flow directions are also discussed.
Scaffolds containing pores of multiple sizes may allow preferential transport of cells versus smaller molecules (e.g., nutrients, waste, or growth factors).
Our data show efficient attachment of Aln on the surface of nanoparticles which could be used as a drug carrier for preferential delivery of multiple therapeutic agents to bone microenvironment.
This is the first report describing the existence of multiple forms of SMP30, their preferential distribution to membranes and their generation through proteolysis possibly mediated by secretase enzymes.
Preferential insertion of multiple copies of cognate TEs with different orientation into one "hot spot" may result in the formation of such locus.
This is the first study to systematically examine the preferential usage of multiple exons 1 of the aromatase gene in breast tissue of the very elderly.
Switching of the preferential use of multiple exons 1 during aging might be advantageous to peripherally produce estrogens by increasing aromatase levels.
Those results suggest that differences of aromatase mRNA levels between tissue categories were related to the preferential usage of multiple exons 1 in each tissue category.
Further study is needed to elucidate the molecular mechanism of switching of the preferential use of multiple exons 1 during aging and carcinogenesis.
