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Furthermore, multiple preclinical studies have focused on identifying synthetic lethal interactions with KRAS mutations; however, the majority of these synthetic lethal interactions have not been reproducible [55].
Multiple preclinical studies have demonstrated cardioprotective effects of GLP-1R agonists in experimental models of ischemic heart disease.
Multiple preclinical studies demonstrated that plasma s-Met directly correlated with tumor size in xenograft mice [ 9].
Multiple preclinical studies have shown the safety and efficacy of different variants of developed tissue-engineered bone grafts [ 114] that formed the basis for clinical translation.
These complexities are further underlined by the findings in multiple preclinical studies that acidosis may have direct effects which can protect cells and organs in the setting of acute organ injury.
Multiple preclinical studies have converged on the finding that anti-CXCL12 agents can significantly delay primary tumor growth and metastasis when treatment is started at or close to the time of tumor implantation.
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Multiple preclinical safety studies in various animal models have been conducted to assess the immunogenicity, biocompatibility, and tissue response to Seprafilm [4].
Multiple clinical and preclinical studies and related drug discovery and development efforts are in progress.
Several immunotherapy strategies have been tested for anti-tumor responses alone and in combination with standard care in multiple preclinical and clinical studies.
In the last years there have been multiple preclinical and clinical studies using these viruses as therapeutic agents in the treatment of a broad range of cancers, including osteosarcoma.
Multiple preclinical and clinical studies suggest that the dorsal cochlear nucleus (DCN) plays an important role in the development of tinnitus and could therefore be a target for DBS in tinnitus.
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