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To date multiple preclinical stimulators have been designed and described.
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To date multiple preclinical neural stimulators have been designed and described but have failed to make an impact on the methods employed by the majority of laboratories studying DBS.
Olesoxime (TRO19622) was identified as a potential treatment of SMA based on its beneficial effects in multiple preclinical neurodegeneration models.
The Presto 1000 system was tested across multiple preclinical and clinical settings in parallel with a control predicate TCD system.
The compound also showed excellent efficacy in multiple preclinical animal models related to psychiatric disorders, particularly schizophrenia.
Multiple preclinical safety studies in various animal models have been conducted to assess the immunogenicity, biocompatibility, and tissue response to Seprafilm [4].
Furthermore, multiple preclinical studies have focused on identifying synthetic lethal interactions with KRAS mutations; however, the majority of these synthetic lethal interactions have not been reproducible [55].
Multiple preclinical and clinical studies have demonstrated verbal memory deficits in PTSD following traumatic stress, visual memory being spared.
These therapies provide significant survival benefits, but more importantly synergize with anti-VEGF therapies in multiple preclinical models.
Multiple preclinical studies have demonstrated cardioprotective effects of GLP-1R agonists in experimental models of ischemic heart disease.
The inhibition of autophagy augments the efficacy of anticancer agents in a variety of tumour in multiple preclinical models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com