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Thus, the selection of an initiation region contributes to the proteasome's ability to discriminate between multiple potential substrates.
22, 25 Multiple potential substrates and receptors for tPA have also been proposed to mediate these diverse effects, including plasminogen, NMDA receptors, LRP1, and PDGF-CC.
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To gain an overview of how the severity of ER stress influences AKT downstream target substrate recognition, we used an anti-phospho-AKT substrate (RXRXXS/T) antibody that detects the phosphorylation status of multiple potential AKT substrates.
In this regard, multiple potential protein substrates of Nedd4 1 have been identified, such as Rap2A and IGF1-R.
Since kinase-substrate specificity is often mediated by additional binding events at sites distal to the phosphorylation site, the predictor uses the presence/absence of multiple sequence motifs to evaluate potential substrates.
TSO was chosen as our model substrate because of its size; it almost completely fills the StEH1 active site, thus avoiding the complications that would arise from the multiple potential binding modes expected with smaller substrates.
Given their physical interaction with TORC1, all of these proteins, in addition to multiple other, as-yet-unconfirmed interactors, are potential substrates (or regulators) of TORC1.
Of note inspection of the primary structure of EFA6 revealed multiple potential ERK/MAP kinase phosphorylation sites that suggest that EFA6 is a substrate of ERK downstream of A-RAF.
Africa has multiple potential tipping points at once.
In this study, we used FA-based multiple reaction monitoring (MRM) approaches to screen for potential acyltransferases in the EUROpean Saccharomyces Cerevisiae ARchive for Functional analysis (EUROSCARF) library to characterize potential substrates for annotated acyltransferase genes.
Such potential substrates include proteins that establish cell-cell contacts.
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