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As multiple positive findings were expected and found, the false discovery rate q value was calculated to quantify the joint probability of multiple findings reflecting true associations as opposed to false positives, taking into account all comparisons performed to test the three hypotheses.
Lastly, in those instances in which there were multiple "positive" findings for a given BCS case, the classification could be expanded to include concordant findings, disconcordant findings, or both simultaneously concordant and disconcordant findings.
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On the other hand, kudos to the Media Matters piece entitled, "Media Cherry-Pick Facto to Falsely Label Head Start Program a Failure," which dispassionately lists multiple positive scientific findings from Head Start over the years, including those that extend into later life such as increased high school graduation rates and decreased crime.
Accordingly, clinical examination is inaccurate both for predicting the presence or absence of nerve root impingement, and for clarifying the relevant level and side in patients with multiple positive imaging findings.
Accordingly, the tests are not very helpful in clarifying the cause of radicular pain, and are therefore inaccurate for treatment guidance of patients who often have multiple positive imaging findings.
They write in their paper that "misreporting of influenza is likely to be considerable". They also note in the last sentence of their abstract that "The results may be due to multiple testing; the few positive findings are potential chance findings". Results from other groups on the outcomes of fever or influenza infection during pregnancy are mixed.
To address the concerns of multiple testing and false positive findings, all genotyped data are publicly available (LONI, http://www.loni.ucla.edu/ADNI/Data/) for combining with other datasets and for other analytical approaches by the scientific community.
Since there are usually multiple variables that merit subgroup comparisons, the risk of false positive findings due to multiple comparisons compounds the risk of false negative findings due to low statistical power.
The capacity of multiple comparisons to produce false positive findings in genetic association studies is abundantly clear.
In 1990 Kenneth Rothman proposed that attempting to reduce the number of false positive findings with multiple testing adjustments can hinder observation and impede the advancement of science.
Again and again – The intervention program needs to be replicated across multiple studies; one positive finding isn't enough.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com