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Alternatively, the intron may contain multiple positive elements situated upstream and downstream of position 5810.
Similar(59)
Altogether, these data suggest that an important regulatory element does not straddle position 5810, and that the absence of multiple positive regulatory elements (situated between positions 5811 6221 and 7573 8167), cumulatively, is responsible for the low level of activity observed with 2.7hPLPΔ5811 to 8167.
Taken together, these results indicate that multiple positive regulatory elements reside between intron 1 position 3874 and 5810, which are active in Oli-neu cells, and are functionally redundant.
These data suggest that the INO promoter contains multiple positive regulatory elements sufficient for the proper pattern of INO expression, but these elements are not individually sufficient to induce expression to a detectable level.
Thus, hPLP1 expression is controlled via multiple positive regulatory elements in intron 1.
Deletion analysis indicates that the intron contains multiple positive regulatory elements which are active in Oli-neu cells.
The intron contains multiple positive regulatory elements that are required for maximal expression of hPLP1-lacZ constructs.
Establishment of this pattern requires cooperation and competition between multiple positive and negative regulatory elements.
Alternatively, upregulation of IFN-stimulated genes, but not of IFNB, may reflect the complex transcriptional regulation of IFN gene expression with multiple positive and negative regulatory elements.
The commune had some positive elements too.
The new strategy does contain some positive elements.
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