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Comparison of these initial studies indicates that broad systematic comparisons of multiple populations are required to provide an unbiased scan for loci under locally varying selection.
The sample set from England showed the greatest degree of deviation from HWE (significant at 3 loci for heterozygote deficit) which could be because of the Wahlund effect (seen when multiple populations are grouped together as one; Wahlund, 1928).
Therefore, in the initial population stage, different individuals in multiple populations are randomly assigned different numerical sizes.
We have confirmed that two loci, IL23A and TNIP1, associated with psoriasis in multiple populations, are also associated with PsA.
In experimental studies, multiple populations are exposed to similar selection pressures and whole genomes are sequenced, providing high-density maps of genomic events.
The predictability of evolution at the phenotypic level can also be observed in natural populations, in particular when multiple populations are evolving in response to similar selection pressure.
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Second, genome bins that clearly consisted of multiple populations were re-binned using MetaBAT specifying increasingly more stringent sensitivity parameters, until 'contamination' in each bin was minimized.
In this paper, multiple populations were introduced to obtain sets of parameter values that optimize the objective function.
For ease of notation, we consider a one-population model ((M=1)); the generalization to multiple populations is then straightforward (see Sect. 3.4).
These multiple populations were mostly found homogeneously distributed within the necrotic core of granulomas with a smaller proportion in the surrounding acellular rim.
Each population was tested as a separate experiment in environments where multiple populations were evaluated.
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