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Initial studies by our group indicated multiple polymorphisms in these other regions, many of which were not in significant linkage disequilibrium with the coding polymorphisms [9] [11].
Within drusen, the association of lipid components plausibly derived from lipoproteins with strong signals from complement-related molecules is especially intriguing, given the multiple polymorphisms in complement factors that influence AMD susceptibility [14], [15], [16].
Few previous studies have examined multiple polymorphisms in relation to PH associated with COPD.
These results suggest that multiple polymorphisms in antioxidant defense genes may modify risk of developing idiosyncratic drug reaction in general.
Here we have extended and optimized the use of the method for multiple polymorphisms in the NAT1 gene.
Multiple polymorphisms in the coding sequence and promoter region of VDR may alter the immune response and specific VDR variants are associated with several immune-mediated liver diseases.
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As for now, our research draws attention to the importance of analyzing whether multiple polymorphisms work in concert to bring about phenotypic differences.
Multiple polymorphisms were examined in the IL10, TNFRSF6, TNF, TGFB1 and MBL2 genes by PCR haplotyping.
TYK2 promoter variant with multiple polymorphisms was identified in the Japanese.
These methods included genetic diversity analysis to detect genes with unequal distribution between five subpopulations; and finally, an analysis of substitution rates was applied to genes with multiple polymorphisms to identify genes in which sequence variation may have functional consequences.
We performed LD and haplotype analysis to further characterize the occurrence of multiple polymorphism sites in strong association with D M ratio.
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