Sentence examples for multiple polymorphic sites from inspiring English sources

The existence of multiple polymorphic sites in the human genome modulating gene expression level is supported by eQTL analyses.

These association studies have highlighted multiple polymorphic sites that are associated with chronic kidney disease and diabetic nephropathy development.

A unique haplotype is then a sequence characterized by multiple polymorphic sites corresponding to the same and unique allele.

A total of 33 pairs of primers were designed since in a few cases multiple polymorphic sites could be amplified in a single fragment.

For a little more than half of the nuclear sequences, due to multiple polymorphic sites in heterozygous individuals, PCR products were cloned into a pGEM vector (pGEM™-T EasyVector System I, Promega), averaging three clones per polymorphic sequence.

However, there are some indications that only two haplotypes may be present: (1) all variable sites were bimodal (e.g., either an A or G); and (2) in 5 instances, multiple polymorphic sites were located within a single DNA fragment and in all 5 cases only two versions of the sequence were present.

When the known variation is accounted for, codons 136 and 171 each have multiple adjacent polymorphic sites and may encode up to four amino acids.

The multiple analysis of polymorphic sites in the MnSOD (rs1799725, rs2758330, rs1967802), CAT (rs480575, rs1408035, rs769217, rs2284367) and Gpx1 (rs3448, rs3811699) genes conducted on a Northern Irish population showed no significant association with AMD (Esfandiary et al. 2005).

Variants can differ in the locations of their predicted stop codons, resulting in predicted proteins of distinct lengths, and also by the presence of multiple polymorphic insertion-deletion (indel) sites within the protein coding sequence (CDS).

To address this problem, we employed an alternate approach to phylogenetic reconstruction targeting multiple polymorphic markers from anonymous sites across the genome.

To select the regions for amplification, we started from a multiple sequence alignment containing putative polymorphic sites, and identified regions in the alignment that correspond to blocks of conserved sequence (100% identity, devoid of indels and putative SNPs).