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Among the multiple pleiotropic responses elicited by AHR agonists, the antiestrogenic and endocrine-disrupting action of the receptor activation is one of the most studied.
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In addition, by combination of RT-PCR and microarray analysis, we showed that the cellular responses to artemisinic acid biosynthesis involve the induction of multiple pleiotropic drug resistance genes [ATP-binding cassette (ABC) and major facilitator superfamily (MSF) transporters] as well as genes known to respond to oxidative and osmotic stresses.
Given that cyc encodes a positive transcriptional regulator, multiple pleiotropic effects are possible, and even likely.
Most importantly, we are far from uncovering the multiple, pleiotropic functions of genes.
That PPARα agonism results in pleiotropic responses should not be surprising.
This gene encodes a signaling peptide, ASIP, that influences melanocytes but also has multiple pleiotropic effects (Dreger and Schmutz 2011).
Both traits are critical for wheat performance in the field and are known to have multiple pleiotropic effects.
This co-localization suggests that it may be a good candidate for further investigation of the pleiotropic response to stress.
In vitro and in vivo studies revealed pleiotropic activities of IL-10 on B and T cells and taken together, that a critical function of IL-10 is to suppress multiple immune responses through individual actions on T cells, B cells, antigen presenting cells and other cell types and to skew the immune response from Th1 to Th2 [ 34].
TRPV1, also known as the capsaicin receptor, belongs to a larger family of non-selective cation channels responsible for a series of pleiotropic biological responses [35].
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