Sentence examples for multiple pleiotropic effects from inspiring English sources
This gene has multiple pleiotropic effects on macrophage function, including regulation of cytokine production, tumor necrosis factor α, interleukin-1 β, inducible nitric oxide synthase and regulation of major histocompatibility complex class II expression and antigen presentation functions [7], [8].
Given that cyc encodes a positive transcriptional regulator, multiple pleiotropic effects are possible, and even likely.
This gene encodes a signaling peptide, ASIP, that influences melanocytes but also has multiple pleiotropic effects (Dreger and Schmutz 2011).
Both traits are critical for wheat performance in the field and are known to have multiple pleiotropic effects.
However, these loci may not be universal genetic factors for autoimmune disorders; therefore, the autoimmunity might result from specific and multiple pleiotropic effects [ 19].
Recent bio- and neuroinformatics approaches allow the in silico identification of QTLs and multiple (pleiotropic) effects of single genes, without any a priori hypothesis [ 182].
The combined effects lead to a 50% higher TGW in NILs with the loss of function OsGW2 allele, and multiple other pleiotropic effects.
As detecting epistatic effects on individual genes is widely known as a computationally intensive task, the more challenging problem of detecting epistatic effects on multiple genes with pleiotropic effects would require a significant advance in computational tools.
RP is usually non-syndromic (70 to 80%), but there are also more than 30 syndromic forms, involving multiple organs and pleiotropic effects, the most frequent being Usher syndrome (USH; approximately 15 to 20% of all RP cases).
It is unclear whether QTL clusters associated with multiple traits represent the pleiotropic effects of a single gene or close linkage of different genes affecting different traits.
Hha affects the production of multiple proteins and causes pleiotropic effects for genes related to catabolite repression [21]; Hha also affects other phenotypes including plasmid supercoiling [52] and insertion sequence transposition [53].
