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Advances in imaging and metabolic analysis techniques indicate that M. tuberculosis preferentially associates with foamy cells and employs multiple physiological systems to utilize exogenously derived fatty-acids and cholesterol.
The results are discussed in terms of the difficulties faced by genetic association studies in teasing apart the behavioral phenotypes that characterize complex psychological diseases and the involvement of multiple physiological systems in human behavior.
This is partly because CAD is a complex phenotype involving multiple physiological systems.
At low levels, ROS are essential for adequate functioning of multiple physiological systems, including intracellular messaging, apoptosis and immunity.
The results very clearly demonstrate that frailty is a condition associated with problems across multiple physiological systems.
Frailty involves a cumulative decline in multiple physiological systems including a decline in the neuromuscular system which is linked to the development of sarcopenia in later life.
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Allostatic load represents cumulative dysregulations which eventually develop across multiple interconnected physiological systems as a result of frequently repeated or chronic activation over the life course.
For the maturation of metabolic pathways, functions obtained with population modeling from in vivo sources reflect the net effect of maturational changes in multiple underlying physiological systems.
While originally perceived as merely biological detergents aiding in the solubilization and absorption of dietary fats, over the past decade it has been demonstrated that bile acids, through their known agonist activity at the nuclear FXR transcription factor, act as hormones involved in multiple different physiological systems as previously described in this manuscript.
Frailty has been defined as a state of increased vulnerability to stressors that results from decreased physiological reserves, and even dysregulation, of multiple physiologic systems [ 1].
Ageing is a complex process influencing multiple mechanisms and physiological systems.
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