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Hydrogen sulfide (H2S) has multiple physiological roles, for example, in vasodilation and inflammation.
Dipeptidyl peptidase IV is an ectopeptidase with multiple physiological roles including the degradation of incretins, and a target of therapies for type 2 diabetes mellitus.
However, in recent years, H2S has been identified as a third endogenous gaseous transmitter after nitric oxide (NO) and carbon monoxide (CO), playing multiple physiological roles in animal systems (Li et al., 2011; Wang, 2012).
Therefore, we suggest that pDBI and bDBI and the active fragments may co-exist in the central nervous system and play multiple physiological roles during the development of morphine tolerance and dependence.
Thus, Drosophila represents an attractive system where to pursue genetic studies identifying the multiple physiological roles of these proteins.
In view of the multiple physiological roles of NO, it is quite possible that the effects on NOS will prove to be related to the success of parasite infection [28].
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Furthermore, although CHEB42A can be secreted, the modulatory effects on DEG/ENaC currents were not affected by the secreted peptide alone, suggesting that CHEB42A may have multiple, distinct physiological roles.
Although LDLR family members were initially studied for their roles in receptor-mediated endocytosis, multiple other physiological roles have been described.
KATP channels are involved in multiple physiological processes, with roles in glucose homeostasis, ischemic protection and innate immunity [ 68, 88].
The activity of 1,25(OH)2D3 is mediated by VDR [ 34]. 1,25(OH 2D3-VDR has multiple physiological and pathological roles that extend beyond the regulation of mineral metabolism, including the regulation of renal and cardiovascular functions [ 35].
The EGFR pathway in Drosophila has become a model for understanding how signaling pathways are regulated with the precision that is necessary to control their multiple developmental and physiological roles (Shilo, 2003).
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