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Frailty has been defined as a state of increased vulnerability to stressors that results from decreased physiological reserves, and even dysregulation, of multiple physiologic systems [ 1].
Frailty is a physiological state characterized by the deregulation of multiple physiologic systems of an aging organism determining the loss of homeostatic capacity, which exposes the elderly to disability, diseases, and finally death [ 10– 10].
In this context, frailty (a geriatric syndrome characterized by age-related declines occurring across multiple physiologic systems) may indeed represent a clinically relevant threshold throughout the continuum of the aging process and a promising benchmark to test multidomain interventions against age-related conditions.
The roots of frailty may lie in alterations to multiple physiologic systems (Walston 2004).
The phenotypes prefrailty and frailty are generally described as reduced resistance to stressors and increased vulnerability to adverse outcomes; a condition probably caused by cumulative declines across multiple physiologic systems [ 4– 6].
It is theoretically defined as a clinically recognizable state of increased vulnerability to stressors, characterized by a decreased reserve capacity to maintain homeostasis resulting from an age-related cumulative decline across multiple physiologic systems [ 1, 2].
Similar(48)
Fatigue/low vitality is often a symptom of underlying psychiatric or medical illness and is increasingly seen as an early indicator of frailty, caused by increased vulnerability in multiple biologic and physiologic systems [ 5].
Albumin has multiple physiologic properties that could be beneficial in central nervous system injury.
Behaviors produced by healthy physiologic systems, however, rely upon nonlinear interactions among numerous feedback loops and regulatory processes that operate over multiple temporal and spatial scales [ 24, 36].
Progesterone appears to affect multiple physiologic processes that follow an acute injury.
This means that chronic sleep deficiency has the potential to impact nearly all of our physiologic systems.
More suggestions(15)
multiple physiologic effects
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multiple physiologic symptoms
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