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Progesterone appears to affect multiple physiologic processes that follow an acute injury.
Thus, the degradation of biomaterials involves multiple physiologic processes at the same time making it a science to its own.
The indolamine, serotonin (5-hydroxytryptamine-5-HT) was identified and initially characterized around the middle of the twentieth century and it is now known to participate in multiple physiologic processes in mammalians.
These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells.
MicroRNAs (miRNAs) are a class of small noncoding RNAs implicated in multiple physiologic processes via negative post-transcriptional regulation of messenger RNAs (mRNAs).
1– 3, 66 It has been proposed that tPA directly affects multiple physiologic processes, such as neuronal development, 67 neuronal plasticity, 68 axonal regeneration, 69, 70 as well as multiple pathologic processes, such as excitotoxicity, 71 microglial activation/inflammation, 72, 73 and BBB dysfunction.
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The interaction between insulin and its receptors triggers the cascade of events associated with multiple physiologic or pathologic processes.
Such a xenobiotic-induced increase in [Ca2+] i is of particular concern because this increase, in addition to being essential for multiple physiologic and pathologic processes, is the trigger for vesicular release of neurotransmitters (exocytosis).
Owing to the complexity of arginine metabolism that underlies multiple biochemical and physiologic processes, however, the potential benefits and risks of arginine supplementation have to be carefully evaluated in further studies by a multiparameter approach measuring additional pathway-related products such as polyamines and ornithine, but also the activity of enzymes.
On the basis of this evidence, we postulate that the presence of pulmonary inflammation may lead to pathology in the heart, whereas zinc may affect broader physiologic processes at multiple levels without apparent lesion development.
In this context, frailty (a geriatric syndrome characterized by age-related declines occurring across multiple physiologic systems) may indeed represent a clinically relevant threshold throughout the continuum of the aging process and a promising benchmark to test multidomain interventions against age-related conditions.
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