He and other experts consider self-neglect a geriatric syndrome like frailty, delirium or falls associated with the deterioration of multiple physical functions as people age.
MiR-374b was reported as being involved in multiple physical functions and diseases, such as adipocyte differentiation [ 43, 44], lipid metabolism, renal Ca2+ homeostasis [ 45], vascular permeability in injury [ 46], and lung cancer [ 47].
For the second approach (described later) we created a Physical Function Index variable that combines multiple physical function variables.
If a respondent had multiple physical function limitations, he or she was considered to be part of more than one RBN group.
HA is a natural molecule component of the ECM from many tissues, including cartilage, with multiple physical and biological functions.
For this purpose, healthy older adults were trained in a standardized group setting with CPT targeting multiple cognitive domains (memory, attention, executive functions) and multiple physical fitness components (strength, balance/coordination, flexibility, endurance) or pure multidomain CT.
However, adults with multiple comorbidities and physical function limitations were excluded from these trials because their comorbidities and functional limitations might interfere with their participation in the interventions (29).
Health-related quality of life, as assessed by the MOS SF-36, is not disease specific and captures quality of life in multiple domains (ie, physical functioning, pain, social functioning, mental health, and general health perceptions).
To our knowledge, our analysis is the first to evaluate the relative impact of multiple comorbidities on physical function in CHF in general, and in HFpEF and HFrEF in particular.
This is not unexpected considering that both limitation scales are single questions as opposed to multiple questions in physical functioning subscale and the pre-operative score on one role limitation subscale (role physical) was lower compared to physical function and pain subscale scores.
Physical performance was measured with the Physical Performance Test (PPT) which assesses multiple domains of physical function by timing how long it takes to perform tasks of varying degrees of difficulty (i.e. writing a sentence, putting on and taking off a jacket, turning around 360 degrees, walking 15 meters) [ 29].
