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Sporadic dystonia is an umbrella term, comprising multiple phenotypic subtypes that may well have distinct genetic architectures.
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Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing.
The observation that these phenotypic subtypes could be established from two independent donor NP pools strongly suggests that multiple different cell phenotypes coexist in the human NP and that these can be isolated as NP subtypes and propagated as immortal cell lines.
Pleiotropy occurs when a single genetic loci influences multiple phenotypic traits.
Since this study employs multiple phenotypic scales, the potential exists for type I errors.
Finally, senescent cells undergo multiple phenotypic and functional changes.
Some alleles were associated with multiple phenotypic classes.
These subtypes could be related to different cells of origin in the colonic crypt, and gene expression signatures were proposed to identify these phenotypic subtypes.
CADASIL is an example of pleiotropism i.e. single gene effects on multiple phenotypic traits.
There are also tools that provide an overview of multiple phenotypic properties (interactions, localization, etc).
Altogether, the data indicate that BM-MSC and SM-MSC shared multiple phenotypic and functional properties.
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