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The transitions in the malignant cancer progression are dynamic and reversible steps between multiple phenotypic states (e.g. epithelial and mesenchymal phenotype) [ 385].
These experiments are not intended for hypothesis generation across hundreds of potential chemical factors with multiple phenotypic states.
Several well-studied natural gene networks can be found in multiple phenotypic states depending on the history that the cells have experienced, notably including the yeast galactose utilization network and sporulation commitment in Bacillus subtilis (Acar et al., 2005; Igoshin et al., 2006).
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Although trivial, one often forgets that multiple distinct phenotypic states can be produced by the very same genome, which is the foundation for non-genetic switching between functional states during tumour progression.
Since this study employs multiple phenotypic scales, the potential exists for type I errors.
Here we found experimentally that several phenotypic states lost resilience to multiple environmental perturbations near a critical transition.
Phenotypes associated with QTLs are evaluated using specific genetic materials that provide contrasting phenotypic states.
In this way, alternative regulatory phenotypic states would be inherited.
Pleiotropy occurs when a single genetic loci influences multiple phenotypic traits.
Genetically identical cells may exhibit diverse phenotypic states even under almost identical environmental conditions.
Epigenetics refers to heritable, but potentially reversible, alternated phenotypic states without difference in genotype.
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CEO of Professional Science Editing for Scientists @ prosciediting.com