As an initial step toward the above notion, we confirmed that diabetic SIECs in culture exhibited multiple angiogenic phenotypic features that were reminiscent of those documented in the in vivo sponge implants retrieved from GK rats with type 2 diabetes.
9 The combination of similarities based on multiple structural, biological, and phenotypic features has led to the discovery of new drug indications.
Other risk factors include genetic predisposition reflected in the phenotypic features of multiple moles, fair complexion, sunburn-susceptible skin types, and family history.
We also note that several other ubiquitin-protein ligase genes (PARK2, NEDD4, TRIM9, NHLRC1, CBL, TRIM63, RNF19, and so on) have been implicated in multiple Mendelian diseases sharing similar phenotypic features as the current patients.
The diverse effects of single mutations on multiple phenotypic traits, called pleiotropy, are a key feature of the genotype phenotype map with fundamental evolutionary consequences (Fisher 1930; Otto 2004; Østman et al. 2011; de Visser et al. 2011; Wagner and Zhang 2011).
62 Vitamin A is also required for conditioning of DCs and promoting the stereotypical phenotypic features of intestinal CD103+ DCs, 58 highlighting the fact that multiple cell types are modulated by vitamin A and underscoring the important role it plays in immunity.
In 1993, Ewart et al. [ 3] reported that haploinsufficiency of multiple genes, including microdeletions of the elastin gene locus at 7q11.23, contribute to the phenotypic features of WS.
In general, annotation of less specific phenotypic features might decrease the observed overall similarity between phenotypes.
Extensive family history data from multiple sources provided information on the demographics and health status of first-degree relatives, including common phenotypic features of 22q11.2 DS.
Note that, for Williams syndrome, we identified many phenotypic features that were associated with more than one candidate gene, i.e. multiple different genes all produce a similar phenotype.
