Sentence examples for multiple phenotypic changes from inspiring English sources

This glycolytic switch will trigger expression of stem cell markers such as CD133 and multiple phenotypic changes that result in increased invasion, migration and angiogenesis.

Our comparative genomic studies provided, for the first time, a molecular roadmap that allows us to address the basis of virulence attenuation and the multiple phenotypic changes of H37Ra.

Although multiple mutations in noncontiguous chromosomal loci of H37Ra collectively lead to multiple phenotypic changes including virulence attenuation, it is likely that one or two initial mutations affecting global metabolic regulation might provide some advantage for in vitro survival under the conditions of aging and cell lysis (Figure 5).

The knockout mouse displays multiple phenotypic changes with some dying in less than 2 months, developing early stage growth retardation, and having shorter lifespan overall.

PC-3 prostate tumour cells were substantially more sensitive to clusterin expression than nonmalignant PNT1a cells, showing multiple phenotypic changes including cell cycle arrest and increased apoptosis.

In the light of these well-established embryological observations, we posit that the multiple phenotypic changes characterizing the DS reflect a developmental reduction in neural crest cell input to all of these affected traits.

While tobacco smoke produces multiple phenotypic and genotypic changes in P. gingivalis [28] and, thus, other yet to be identified mechanisms may well contribute to the overall reduced inflammatory response, the anti-inflammatory effects of recombinant FimA are potent and are likely to be a major factor in CSE-induced inflammatory suppression.

Finally, senescent cells undergo multiple phenotypic and functional changes.

Consistent with this model, replicatively stressed CD4+ and CD8+ T cells undergo multiple phenotypic and functional changes (Fig. 2) [ 45].

Multiple environmental drivers of phenotypic changes can act in synergy and accelerate the rate of extinction (Brook et al. 2008).

A total of 163 nontandem duplicate genes that were related to 75 kinds of phenotypic change were classified into 26, 89, 32, and 16 genes whose multiple-knockout mutants showed phenotypic changes in the seed, vegetative, reproductive, and conditional phenotypes, respectively.