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We suggest that multiple phenotypic associations between plasma lipid levels with BMD and common traits in MS, be affected by the common genes harbouring pleiotropic effects.
Among multiple phenotypic associations with high TG, we considered the phenotypic associations which subdivided samples into feasible sizes of cases and controls for GWAS.
This work reports a novel data mining approach to discover patterns of multiple phenotypic associations over 52 anthropometric and biochemical traits in KARE and a new analytical scheme for GWAS of multivariate phenotypes defined by the discovered patterns.
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Finally, previous phenotypic associations have been reported for multiple cortical phenotypes all of which are strongly correlated with one another or are nonindependent.
Some alleles were associated with multiple phenotypic classes.
Firstly, we use gene signatures to understand the relationship between non-coding RNA and a given cancer phenotype; this exploits the phenotypic associations intrinsic to established gene signatures.
Multivariate phenotype highLDLhighTG increased the strength of phenotypic associations with the correlated single traits by additive effect of multiple single traits.
Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts1,2,3,4.
Finally, at the organismal level, pleiotropy is detected when changes in a single locus lead to multiple phenotypic effects.
Our current index (see Fig. 1, Methods) can be used for exploring other phenotypic associations at the population level in future studies.
Phenotypic associations between the variables were low to moderate, with Pearson's correlations in the range 0.17 0.32.
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CEO of Professional Science Editing for Scientists @ prosciediting.com