After a median follow-up of 42.00 months (range 6 97) monthly moderate-to-severe headache days (i.e. days on which pain was more than 4 on the verbal rating score and lasted at least 4 h) reduced by 8.51 days (p < 0.001) in the whole cohort, 5.80 days (p < 0.01) in those with chronic migraine alone and 12.16 days (p < 0.001) in those with multiple phenotypes including chronic migraine.
Kto/med12 mutants show multiple phenotypes, including defects in brain, neural crest, and kidney development.
In P. fluorescens Pf-5, the GacS/GacA system controls multiple phenotypes, including secondary metabolite and exoenzyme production, stress response, and motility [15], [16], [17], [46].
Methods to differentiate hESCs into multiple phenotypes including endoderm, mesoderm, and ectoderm, as well as trophoblast and germ cells, have been reported [1] [4].
Myc deregulation in many cell types, including Rat1a fibroblasts, affects multiple phenotypes, including proliferation, apoptosis, and GI [14], [15], [16], [19].
A conventional deletion of the gene for cGKI has been studied in mice and multiple phenotypes, including elevated BP, have been observed [37].
Characteristics of aNSC are long-term self-renewal capacity and multipotentiality as they differentiate into multiple cell phenotypes, including neurons.
The chromosome 9p21.3 region has been identified as a genetic susceptibility locus for multiple disease phenotypes including coronary artery disease, diabetes and cancer (Pasmant et al, 2011).
Our findings show immune signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes including alcohol, smoking and opioid addiction.
Notably, conditional DICER deletion studies in the mouse visual system lead to multiple retinal phenotypes, including increased apoptosis and impaired retinal development, differentiation, and maintenance (reviewed by [ 16]).
Comparison of wild-type and the ΔartA mutant strains resulted in multiple biological phenotypes including alteration in cell shape and the S-layer.
