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Angio CT evaluation of living kidney donors is a multiple phase study.
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One of the major issues in drug development is the absence of correlation between preclinical data and trial results leading to failure of multiple phase III studies, in part due to the poor predictive value of cell line studies [ 19, 20].
Clinical investigation of poly(ADP-ribose) polymerase (PARP) inhibitors for ovarian cancer treatment has rapidly evolved from observations of single-agent in vitro activity of these agents in BRCA-deficient cancer cells in 2005 to the initiation of multiple phase III studies in 2013.
Based on these findings, multiple phase II studies have been initiated.
This dosing schedule is being further evaluated in multiple phase II studies.
Table 1 summarizes the survival rates of different patient populations treated in multiple phase II studies 25.
Multiple phase I studies have proven MRI-guided and US-guided FUS ablation of breast cancer to be technically feasible and safe.
91 Multiple Phase I studies are currently testing the efficiency of 17-AAG in combination with other chemotherapeutic agents in solid cancers of different origin (NCT00121264).
All three second-generation TKIs have demonstrated clinical benefit in multiple Phase II studies 8– 14 in patients with resistance and/or intolerance to imatinib.
Taken together, results from multiple phase III studies support the use of angiome analyses to identify potentially useful prognostic and predictive markers.
This material has undergone nine clinical trials, including multiple phase III studies, and it is currently in a phase III clinical trial for use as a topical microbicide for bacterial vaginosis.
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