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Recently, elderly volunteers (mean age 67.1 yrs; range 61-77 yrs) were treated with SRT2104, a selective small molecule activator of SIRT1 or placebo once daily for 28 days, exploring multiple pharmacodynamic endpoints [ 238].
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However, DV-1179 did not achieve the pharmacodynamic endpoints related to reduction in IFN-α-regulated genes69.
The objective of this study was to characterize the propofol-fentanyl interaction in Beagles for four pharmacodynamic endpoints: apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation.
RESULTS: Response surface models adequately characterized all pharmacodynamic endpoints.
The fast symptomatic resolution of uUTI under Canephron® N treatment supports the assumption that the multiple pharmacodynamic targets of Canephron® N are suitable for the treatment of uUTI.
Pharmacodynamic endpoints were summarized using the per protocol population.
Pharmacodynamic endpoints included UGE, and plasma glucose and insulin concentrations.
Mechanistic and pharmacodynamic endpoints should also be included (Yang et al, 2001; Corpet and Pierre, 2003).
We also explored correlations between grip force and liking scores and other pharmacodynamic endpoints.
Pharmacodynamic endpoints and preliminary efficacy evaluations are ongoing in the expansion cohort.
There were no marked differences between the age groups across the secondary pharmacodynamic endpoints (Table 2).
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