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TCRs are also cross-reactive, capable of recognizing multiple peptides bound to one or more MHC molecules.
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αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules.
The general methods for preparing multiple overlapping peptides bound to cellulose membranes have been described in detail [ 35, 6, 12].
By determining the amino-acid sequences of almost 2,500 HLA-B*57 01-bound HLA-B*57 01-boundearcHLA-B*57 01-bound an enormous shift in peptidespresentheion: 20–25% of the peptides bound by the HLA molecule following dresearchersnt demonstratedm those than bound benormousd.
For instance, tyrosine-phosphorylated peptides bind to PKM2 and decrease its PK activity favouring cell growth53.
Both peptides bind to the active-site on the protein.
Structure of the stapled p53 peptide bound to Mdm2.
(d) Dose-dependent retrieval of VIP peptide bound to its receptor on the surface of liposomes.
As expected, HIF-2α WT peptide bound robustly to pVHL following HIS6-PHD2 treatment (Fig. 5a).
(e,f) Quantification of salusin-β-FAM peptide bound to HeLa cell surface.
Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin.
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