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Signaling of ghrelin receptor is complex and multiple pathways with frequent cross-talk of signaling components have been described in several cell types.
We hypothesize that these mutations gradually accumulated via multiple pathways, with variants containing all five hotspot mutations (U25A+C26A+G54A+U193C+U281A), or 4 of the 5 mutations (U25A+C26A+G54A+U281A), eventually becoming predominant in the population.
It has antiapoptotic activity and can target multiple pathways with promising role in many malignancies.
Edoxaban is primarily eliminated unchanged through multiple pathways, with approximately 50%% of systemically absorbed drug eliminated via renal excretion.
Similar to T2DM, diabetic complications are complex phenotypes determined by multiple pathways with a large genetic component.
By gene array, we found consistent alterations in multiple pathways with known relationship to PAH, including actin organization, immune function, calcium balance, growth, and apoptosis.
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Queries requesting the reactions and pathways associated with kinases harboring RD pocket variants reveal that CHEK2 controls multiple pathways associated with cell cycle control and DNA damage repair upon activation loop phosphorylation [Xu et al., 2002] (Table 1).
While it is difficult to predict the particular biological roles of the markers that contribute to the ovarian cancer pathology, they are all implicated in multiple pathways associated with tumor growth and metastasis.
Pathway analysis indicated that multiple pathways associated with transcriptional regulation and supported by multiple independent databases, e.g. GOTERM, BIOCARTA, OMIM disease, etc., were enriched within the shared set of genes that were down-regulated in children with autism and children of older fathers (figure 4c).
From multiple pathways associated with the temporal up-pattern, the core microRNA targets selected were CCNA2, PTTG1, CDK1, CCNB2, CDC25B, CCL7, MAPK12 and ESPL1.
In this preliminary study, we have not yet compared the multiple pathways model with the single pathway model regarding prediction of future cancer cases and evaluation of treatment protocols for human colon cancer.
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