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Given that the pathogenesis of HFD-induced steatosis may involve multiple pathways, the lack of significant change in TG accumulation following rapamycin treatment could potentially be explained by other mechanisms that affect lipid metabolism besides mTORC1.
If an invasive species is regularly transported along multiple pathways, the probability of its successful establishment is increased (Kolar and Lodge 2001).
Although prolactin can transduce signals through multiple pathways, the activation of STAT family members, which are downstream of prolactin and other growth factors has also been implicated in tumourigenesis [ 16, 17].
In addition, as previous studies [ 4, 14, 15] suggested, exercise-induced neuroprotection may involve multiple pathways; the key role of Hsp expression as well as its interactions with other molecular pathway will be further investigated in our future study.
The degenerative processes in PD are likely to involve multiple pathways; the goal of our field should be to identify components of the disease mechanism that can be targeted pharmacologically.
To assess the presence or absence of a metabolic pathway and to decrease the likelihood of being misled by the many enzymes that are shared among multiple pathways, the analysis was emphasized on the presence of enzymes that are unique to a pathway.
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For the multiple pathways tested, the Benjamini-Hochberg (1995) method was applied to control the false discovery rate (FDR < 0.1) [ 54].
Harvard Medical professor Clifford Woolf compares the nervous system to a computer, with multiple pathways between the spinal cord and the brain.
The most persuasive argument that RA has multiple pathways to the same phenotype is the diversity of responses to highly specific immunotherapies.
The agreement between the clustering results based on multiple pathways and the original partitions was also evaluated by calculating the ARI.
From the TGN, multiple pathways to the endosomal system arise, mediating delivery of essential components to various endosomal intermediates.
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