HGF-mediated Met activation and signaling can induced multiple pathways that are involved in stimulating cancer cell proliferation, survival, motility, angiogenesis, invasion and metastasis.
In model iYL_2.0, there are multiple pathways that could supply the above essential molecules, including citrate shuttle and conversion from the TCA cycle, amino acids degradation, and other acetyl-CoA generation process (Beopoulos et al. 2011).
Recent insights into the elements that regulate immune responsiveness have provided new opportunities to enhance the efficacy of cancer vaccines through multiple pathways that involve afferent and efferent arms of the immune system.
Here we review the multiple pathways that underlie effective lung immunity in health, and discuss how these may be affected by external environmental factors and contribute to chronic inflammation during disease.
This article reviews the multiple pathways that have been shown to promote androgen independence, including a recently described mechanism that involves androgen receptor proteolysis to a constitutively active ligand-independent isoform.
Overall, this investigation revealed that schizophrenia is a dynamic process caused by dysregulation of multiple pathways that are in crosstalk.
Several reactions are used by multiple pathways that are temporally distinct, presenting a regulatory challenge to the cell.
Recently, Parp has been implicated in multiple pathways that regulate gene expression, including effects on chromatin structure [46], [47] and transcriptional activator and coactivator functions [48].
Understanding multiple pathways that cooperatively contribute to tumor progression is of utmost importance for development of new therapeutic agents in prostate cancer.
The BRCA1 protein functions in multiple pathways that maintain genomic integrity through its impact on the repair of a variety of genomic lesions including DNA double-strand breaks (DSBs).
Examination of the most significantly regulated genes in pathways reveals that a number of genes from a few different gene families play a repeated role in multiple pathways that were regulated by chemical exposures.
