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Ethanol induces free radical formation through multiple pathways, resulting in steatohepatitis and cirrhosis with chronic use [ 15, 16].
Often, in the United States, characterization of a hazardous waste site reveals multiple chemicals from multiple pathways resulting in a complicated matrix of chemicals and concentrations.
To summarize, sewage workers are exposed to multiple chemicals from multiple pathways resulting in a complicated matrix of exposure to chemicals and concentrations.
The progression of cancer is a multistage process arising from the additive or cooperative activities of multiple pathways, resulting from the activation of proto-oncogenes and inactivation of tumor suppressor genes.
Human leukaemia cell line (HL-60) treated with EO of Cymbopogon flexuosus and its major constituent isointermedeol has been reported to lower NF- κB which is one of the contributing multiple pathways resulting in apoptosis [ 58].
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They affect a large number of genes involved in multiple metabolic pathways, resulting in an integrated, simultaneously up- or downregulation of metabolites in these pathways.
Ionizing radiation produces several types of cellular response via activation of multiple transduction pathways resulting in cell death, differentiation, or proliferation.
This architecture permits the integration of multiple signaling pathways resulting in quorum responses that require a "quorum" but are otherwise highly adaptable and receptive to environmental conditions.
Subsequent studies showed that application of PGE2 to cultured murine keratinocytes or to murine skin caused the activation of multiple signaling pathways resulting in proliferation [ 9].
Although the primary function of the UPR is to protect cells against ER stress, prolonged or unalleviated ER stress may eventually activate multiple apoptotic pathways resulting in cell death [ 11].
It has been proposed that OS may contribute to carcinogenesis by increasing the frequency of genetic mutations and that ROS act as second messengers in multiple intracellular pathways, resulting in malignant transformation 34.
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