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Cell-specific activation of multiple pathways is potentially advantageous from a therapeutic perspective, especially when it can be induced with a single reagent.
Thus, because the different cellular systems in B. subtilis remember different aspects of prior history, the combined activity of multiple pathways is able to combinatorially store more information about the past than can any individual pathway.
Considering that these approaches should target both apoptotic and autophagic pathways, deciphering the detailed molecular mechanism by which CK2 modulates chondrocyte death via multiple pathways is an important and challenging task.
We also illustrated how to quantify memory in multiple combined variables, in the process showing that because the different cellular systems in B. subtilis remember different aspects of prior history to different degrees, the combined activity of multiple pathways is able to combinatorially store more information about the past than can any individual pathway.
As the transcriptional pathways that regulate cell proliferation and differentiation during lung formation are reactivated during regeneration of pulmonary cell lineages following injury, determining how Sox proteins and other transcription factors integrate signals from multiple pathways is important toward understanding the regulatory mechanisms that control lung development and homeostasis.
The functional variability of genes/proteins that participate in multiple pathways is evaluated.
Similar(47)
Drugs that act on multiple pathways are being developed, and targets that are expressed across all phases of the disease are selected.
These data indicate that multiple pathways are involved in the underlying mechanisms of MPP+-induced neurotoxicity, including apoptosis, oxidative stress, iron binding, cellular metabolism, and signal transduction.
Multiple pathways were significantly impacted in AuNR-treated MDA-MB-231 cells, including Huntington's disease, ribosome, spliceosome, pathways in cancer, RNA degradation, endocytosis, glycolysis/gluconeogenesis, apoptosis, insulin signaling pathway, regulation of actin cytoskeleton, etc.
In this study, the general rate equations for cyclic reaction networks with multiple pathways were applied to derive the rate equation and hydrogen yield equation for ethanol steam reforming.
Contextual understanding of the ecosystem is essential in drawing insights from patterns revealed in network analysis, and caution is advised in deriving causal statements, as multiple pathways are often visible.
More suggestions(15)
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