In addition, miRNAs could have unexpected implications in this pathology, because miRNAs regulate multiple pathways in the brain in which minimal changes in gene expression or regulation could be fatal (76).
Similarly, it is likely that the SAGA complex components, including Gcn5, regulate multiple pathways in response to CG-1521, which protect the cell.
Hsp90 expression levels seem to be upregulated in cancer, resulting in addiction of tumor cells to multiple oncogenic pathways in which Hsp90 clients play a critical role.
This mechanism suggests that SBL has an innovative antitumor effect that can cause cancer-selective induction of apoptosis by multiple signaling pathways, in which RNA is its target.
How glucose promotes ROS generation in yeast is not known, but multiple biochemical pathways in which glucose metabolism can generate ROS in mammalian cells have been reported, including glyceraldehyde autoxidation, protein kinase C activation and oxidative phosphorylation.
Among the multiple biologic pathways in which NHERF1 is involved, the signaling event that is most relevant to NHERF1 pathobiology in mammary gland is not known, nor is it certain that NHERF1 elicits tumour suppressor activity in breast.
Given the multiple metabolic pathways in which valine is involved (e.g. glucosinolate [ 91] and pantothenate biosynthesis [ 92], conjugation to plant hormones [ 93, 94]), it would be highly speculative to associate this gene to adaptive processes in the C. resedifolia lineage.
Instead, our data lend support to the idea that more effective treatments need to be developed, which block multiple pathways in parallel.
Also, the Basal-like, HER2-enriched, and Luminal B subtypes are characterized by activation of multiple pathways in contrast to the Luminal A subtype, which show low predicted activity for most oncogenic pathways in this study.
Dukanovic, J. & Rapaport, D. Multiple pathways in the integration of proteins into the mitochondrial outer membrane.
