Sentence examples for multiple pathways implicated from inspiring English sources

Taken together, these data demonstrate that Ang-1 can regulate multiple pathways implicated in EC permeability, and cause different effects depending on the specific context.

Activation of IL-6R (IL-6 receptor)/gp130 stimulated multiple pathways implicated in the regulation of tumour growth and metastatic spread [ 13].

We previously demonstrated that micromolar concentrations of imatinib abrogated multiple pathways implicated in RA pathogenesis, including production of proinflammatory cytokines by synovial macrophages, proliferation of FLSs, production of TNF by mast cells, and proliferation of, and antibody production by, B cells [ 12].

This coordinated change, induced by SST on the activity of multiple pathways, implicates a common regulatory mechanism controlling the multiple pathways.

Nintedanib is an oral angiokinase inhibitor targeting multiple signaling pathways implicated in the pathogenesis of MPM, including the VEGF receptor.

Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA).

MIRA-1 treatment resulted in a potent anti-myeloma activity, both in vitro and in vivo, and leads to induction of multiple interrelated pathways implicated in apoptosis of MM cells.

Regulation of TP signaling itself is similarly complex, with multiple kinase-mediated pathways implicated in receptor desensitization, while oligomerization of the distinct TP splice variant products has also been implicated in modulating function [8], [9].

Besides MAPKs, overexpression of Ras can initiate multiple signal transduction pathways implicated in tumorigenesis, as summarized in Fig. 8.

Its effects on multiple key signaling pathways, implicated in the malignant progression of numerous cancer types, make quinacrine an exciting candidate as a chemotherapeutic agent in new types of combination treatments.

The number of citations mentioning tumor necrosis factor alpha has grown explosively since it was first cloned and named in 1984, showing continued and growing interest in this apoptosis-related cytokine centrally associated with multiple pathways and implicated in cancer.